Corticosteroids: Barbiturates appear to enhance the metabolism of exogenous corticosteroids probably through the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may require dosage adjustments if barbiturates are added to or withdrawn from their dosage regimen.
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Intramuscular Administration: In dem injection of the sodium salts of barbiturates should be made deeply into a large muscle, and a volume of 5 mL should not be exceeded at any one site because of possible tissue irritation.
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Phenytoin sodium exerts its effect during the deep anesthesia stage caused by the pentobarbital sodium. This ingredient, due to its cardiotoxic properties, hastens the stoppage of electrical activity rein the heart.
Barbiturates are weak acids that are absorbed and rapidly distributed to all tissues and fluids with high concentrations hinein the brain, liver, and here kidneys. Lipid solubility of the barbiturates is the dominant factor rein their distribution within the body.
Maintenance of an adequate airway, with assisted respiration and oxygen administration as necessary.
Duration of action, which is related to the Satz at which the barbiturates are redistributed throughout the body, varies among persons and in the same person from time to time.
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A long-time medical friend told me many years ago that she had a supply of the needed drug in her home safe that she planned to use if she decided her remaining life was not worth living should she develop a fatal disease. Several years after she developed a degenerative disease that would eventually lead to her death, she took her own life as planned.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution containers permit. Solutions for injection showing evidence of precipitation should not Beryllium used.
An occasional dog may elicit Reflexreaktion responses manifested by Murl movement; however, an unconscious animal does not experience pain, because the cerebral cortex is not functioning.
Nursing mothers: Caution should be exercised when a barbiturate is administered to a nursing woman since small amounts of barbiturates are excreted rein the milk.